Consortium
NExTLi is built as a coordinated Dutch infrastructure: shared standards, shared access pathways, and complementary capabilities integrated across three partners.
The consortium combines internationally recognized expertise in lipidomics, spatial molecular analysis, and FAIR data infrastructure, with established track records in methodological innovation, core facility leadership, and research infrastructure development. Users interact with a single coordinated workflow — not three separate facilities.
How the consortium works
- Single intake and centralized coordination
- Complementary capability nodes across partners
- Shared QC, reporting, and annotation standards
- FAIR data delivery via the NExTLi Data & Analysis Portal
Consortium partners
Amsterdam UMC — analytical and coordinating core
In-depth structural lipidomics, tracer-based fluxomics, low-input and single-cell method development, FAIR data infrastructure (ACDC), imaging-based sample definition, and overall infrastructure coordination.
F.M. Vaz (PI, coordination), E.A.J. Reits, N.N. van der Wel, K.J. Wolstencroft
Leiden University Medical Center — data interpretation & lipid biology
Translational lipid research, specialized expertise in complex glycolipids, sphingolipids, and sterols, lipid data models and annotation frameworks, and co-development of the NExTLi Data & Analysis Portal (iSODA/NeurolipidAtlas).
M. Giera, Y. Mohammed
Maastricht University / M4i — spatial molecular analysis
Imaging-guided and MSI-guided tissue and cellular region selection, automated tissue processing, low-input and single-cell-compatible preparation workflows, and integration with spatial transcriptomics.
R.M.A. Heeren, E. Cuypers
Governance
NExTLi operates as a distributed national infrastructure with centralized coordination and shared strategic oversight. Governance ensures balanced participation of all partners and coherent development of the infrastructure.
- Management team — operational coordination, service delivery, financial administration, hosted at Amsterdam UMC
- Scientific steering committee — senior representatives from all three partners defining scientific priorities, innovation trajectories, and access policies
- User council — representatives from Dutch research groups advising on usability, access conditions, and emerging needs
- Scientific advisory board — external experts providing independent strategic advice and periodic review
Scientific advisory board
Prof. Kim Ekroos
Lipidomics Consulting, Finland
Lipidomics, standardization
Prof. Maria Fedorova
TU Dresden, Germany
Lipidomics, bioinformatics
Dr. Purva Kulkarni
Radboudumc, The Netherlands
FAIR data, bioinformatics
Prof. Gerhard Liebisch
University Hospital Regensburg, Germany
Lipidomics, lipid metabolism
Prof. Andrej Shevchenko
Max Planck Institute CBG, Germany
Lipidomics, spatial omics
NExTLi is designed for interoperability with national research infrastructures including NL-BioImaging, X-omics, and Health-RI, and aligns with international standards through the Lipidomics Standards Initiative, ELIXIR, and Euro-BioImaging.